 | Sour Sensation | Your taste buds have conquered the tangiest of flavors, granting tang resistance to your skin cells. | Mutations | |
 | Spectacular Spicy Shard | A condensed nugget of elemental force. Simply holding it fills you with power. | Trinkets | 2 |
 | Speed Droplet | A mystical droplet that gives you the energy to run faster and longer. (Playground Exclusive) | Trinkets | 3 |
 | Spicy Arrow | An arrow that deals spicy damage and sizzle on hit. | Ammo & Throwables | 2 |
 | Spicy Coaltana | Sear foes with a finely crafted blade, hammered out of tempered spicy globs and always-hot EverChar coal chunks. | Weapons | 3 |
 | Spicy Glob | A collection of spicy shards, baked and shaped into a cubular glob. Perfect for imbuing equipment with special properties. | Materials | 2 |
 | Spicy Safety | Spicy sediment seeps into your bloodstream. The fiery fragments protect you from the chill. | Mutations | |
| Spicy Shard | A fiery splinter from a spicy candy. | Consumables | 2 |
 | Spider Bait | An alluring blend of gnat bits to attract spiders. | Ammo & Throwables | 1 |
 | Spider Candle | A stationary light source that illuminates the area around it. | Building & Utilities | |
 | Spider Cider | A fizzy beverage with a pungent aftertaste. Drinking this helps you traverse webs safely. | Consumables | 0 |
 | Spider Den Anthill: North Entrance | The northern entrance to a large anthill. But judging from the webs and egg sacs, it hasn't been home to ants for some time. | Key Items | |
| Spider Den Anthill: South Entrance | The southern entrance to a large anthill. But judging from the webs and egg sacs, it hasn't been home to ants for some time. | Key Items | |
 | Spider Den Optical Disk | Contains recipes! Load it into a Ranger Station and use the Science Shop to access them. | Key Items | |
 | Spider Nest | A cozy nest for your pet spider. Hatch spider eggs here to raise your own orb weaver. | Buggies | |
| Spider Nest | A relaxing home for your tamed spiders to unwind. | Building & Utilities | |
 | Spider Slider | A delicious burger made of various chunks of cooked spider. Hearty enough to be considered a whole meal. | Consumables | 2 |
 | Spider Stringer | A high quality bow made of sinewy orb weaver chunks. | Weapons | 2 |
 | Spider Venom | Venom taken straight from a spider's gland... thing. Extremely toxic. | Materials | 3 |
 | Spiderling | Angry little baby spiders found wherever adults roam. Drops web fiber on death. | Key Items | |
 | Spiderling | Angry little baby spiders found wherever adults roam. Drops web fiber on death. | Key Items | |
 | Spiderling | | Creatures | 1 |
 | Spiderling Wall Mount | A wall-mounted trophy of a hard-earned kill. Activate to receive a temporary damage bonus against this creature. | Building & Utilities | |
 | Spike Strip | A spikey board that damages any creature that touches it. Perfect for protecting a base from intruders. | Building & Utilities | |
 | Spiky Bur | The iconic spike ball that lives atop many prickly weeds. | Materials | 3 |
 | Spine Nub | A spiny nub harvested from the back of a caterpillar. These spikes could put an eye out. | Materials | 2 |
 | Spinning Wheel | Spin various materials into strong and luxurious threads. | Building & Utilities | |
 | Spiny Water Flea | A spiny version of this ghastly creature that lives in the hostile waters of the pond. Can drop water flea meat and pond moss. | Key Items | |
 | Spiny Water Flea | A spiny version of this ghastly creature that lives in the hostile waters of the pond. Can drop water flea meat and pond moss. | Key Items | |
 | Spiny Water Flea | | Creatures | 3 |
 | Spiny Water Flea Wall Mount | A wall-mounted trophy of a hard-earned kill. Activate to receive a temporary damage bonus against this creature. | Building & Utilities | |
 | Splatburst | A bomb that's covered in a sticky substance. Attaches to the first thing it hits. | Ammo & Throwables | 2 |
 | Splinter Arrow | Sharp and deadly arrow crafted from wooden splinters. | Ammo & Throwables | 3 |
 | Splinter Trap | A heavy duty spike trap designed to seriously hurt. | Building & Utilities | |
 | Splody Rounds | They explode. Nuff said. | Ammo & Throwables | 3 |
 | Sprig Bow | Perform attacks from a long distance. Requires arrows to be useful. | Weapons | 1 |
 | Sprig Curved Fence | A flimsy fence made of sprigs and crude rope. Great for creating a perimeter around other structures. | Building & Utilities | |
 | Sprig Fence | A flimsy fence made of sprigs and crude rope. Great for creating a perimeter around other structures. | Building & Utilities | |
 | Sprig Half Fence | A halved variant of the sprig fence. | Building & Utilities | |
 | Sprig Half Railing | A halved variant of the sprig railing. | Building & Utilities | |
